Disorders of the serum lipoproteins. II. Hyperlipoproteinaemic states.

Primary Hyperlipoproteinaemias Hyperchylomicronaemia (familial fatinduced hypertriglyceridaemia). This condition, which is characterized by gross accumulation of chylomicrons in the serum due to defective clearing of dietary fat, was first described by Burger and Grutz in 1932. Cases have since been recorded under a variety of names, the most common being 'idiopathic familial hyperlipaemia' and 'essential hyperlipaemia'. The basic defect in most, though possibly not all, cases is a deficiency in the enzyme lipoprotein lipase (Fredrickson and Lees, 1966). The disease is inherited as an autosomal recessive and the gene frequency is not known. The severe